The association of the GWTG-HF score with mortality was attenuated but remained significant when adjusting for other measures of heart failure severity such as NYHA class, left-ventricular ejection fraction, NT-pro-BNP and previous hospitalization of heart failure (HR 1.06, 95% CI 1.03–1.09, p < 0.001). This evidence concerns the gene NPPB and hydrops fetalis.