Also, increased levels of IL-6 have been observed in various diseases, not surprisingly in autoimmune diseases such as rheumatoid arthritis (12) and systemic juvenile idiopathic arthritis (13), but also cardio-metabolic diseases like type 2 diabetes (14), heart failure, coronary heart disease (15) and atherosclerosis (16), as well in cancers (17), atopic dermatitis (18) and psychological disorders like depression (19). The gene discussed is IL6; the disease is systemic-onset juvenile idiopathic arthritis.