However, in contrast with this finding, the IL-6-sIL-6R complex itself is capable of transducing IL-6 signaling to non-IL-6R expressing cells, known as trans-signaling (58), and it is this mechanism, as opposed to classic signaling, that is linked to chronic inflammatory disorders including IBD and RA (59). The gene discussed is IL6R; the disease is rheumatoid arthritis.