Also, increased levels of IL-6 have been observed in various diseases, not surprisingly in autoimmune diseases such as rheumatoid arthritis (12) and systemic juvenile idiopathic arthritis (13), but also cardio-metabolic diseases like type 2 diabetes (14), heart failure, coronary heart disease (15) and atherosclerosis (16), as well in cancers (17), atopic dermatitis (18) and psychological disorders like depression (19). This evidence concerns the gene IL6 and rheumatoid arthritis.