THBD and thrombotic microangiopathy: Interestingly, in contrast with other endothelial vulnerability markers such as nitrates, ST2, asymmetric dimethyl arginine (ADMA), and single nucleotide polymorphisms in the thrombomodulin (THBD) and CD40L genes, pretransplant ANG2 was not associated with transplant-associated thrombotic microangiopathy (TAM) [15].