These data suggest that ASB2β-induced muscle atrophy was associated with marked remodeling of the cytoskeleton and sarcomeres, a phenomenon that is consistent with other models of muscle atrophy, such as muscle denervation (116), and suggest that E3 ligases, including ASB2β, Klhl40, Klh41, and MuRF2, may play roles in this mode of adaptation. This evidence concerns the gene KLHL40 and Atrophy.