SIRT5, a member of Sirtuin family, is known to play important roles in autophagy, apoptosis and drug resistance [30, 31], A study based on online analysis indicated that SIRT5 was positively correlated with complete response to neoadjuvant chemotherapy in triple negative breast cancer, suggesting that SIRT5 might play an inhibitory role in drug resistance [32]. This evidence concerns the gene SIRT5 and triple-negative breast carcinoma.