EGFR and non-small cell lung carcinoma: Other mTOR inhibitors, such as torin2 and BIBW2992) [8, 9] were also reported to be able to induce apoptosis and inhibit cell proliferation in EGFR-TKI-resistant NSCLC cells by negative feedback regulation of Akt/mTOR signaling and inducing autophagy, suggesting promising therapeutic strategy in NSCLC with EGFR-TKI resistant phenotype.