Moreover, we demonstrate overexpression of circZFR promoted the p-Rb S807 and S608 phosphorylation and ac-E2F1 K117 and K125 acetylation using paired cervical cancer and normal tissues, which suggested that circZFR is a central upstream regulator in the activation of Rb-E2F1 signaling. The gene discussed is RB1; the disease is cervical carcinoma.