We tested the hypotheses 1) that 11C-PK11195 binding measured in the three aforementioned regions of interest (ROIs), namely the ACC, prefrontal cortex (PFC), and INS, is significantly increased in depression; and 2) that 11C-PK11195 binding is associated with blood concentration of C-reactive protein (CRP), as a biomarker of peripheral immune status, or body mass index (BMI). The gene discussed is CRP; the disease is depressive disorder.