EGFR and glioblastoma: Recently, it was reported that ELOVL2, an elongase that functions in the synthesis of the long-chain n-3 and n-6 PUFAs, e.g., DHA and docosapentaenoic acid (DPA, 22∶5Δ4,7,10,13,16), respectively, is required for the maintenance of glioblastoma stem cells and that dual targeting of PUFA synthesis and EGFR signaling had a combinatorial cytotoxic effect of glioblastoma stem cells (97).