Based on the above data as well as on previous findings by our group and others in Xenopus oocytes and in several mammalian cell lines, such as neuroendocrine GH4C1, immune RAW264.7, BOSC-23 kidney, or human NSCLC cells (36, 37, 39, 54, 55), we propose that dupα7 subunits could be colocated with full-length α7 subunits in SH-SY5Y cells forming heteromeric dupα7/α7-nAChRs to the detriment of fully functional homomeric α7-nAChR expression. The gene discussed is CHRNA7; the disease is non-small cell lung carcinoma.