PRRT2 and major depressive disorder: Continuous activation of receptors leads to prolonged stimulation of PKC, which was found to promote translocation and subsequent degradation of PKC isozymes; (3) hypothalamic-pituitary-adrenal axis abnormalities associated with depression and suicide induce downregulation of PKC and some of its isozymes and thus may contribute to the observed decline in PKC isozymes; and (4) another speculated factor could be the effect of antidepressants, specifically the DNS group subjects were on chronic antidepressant treatment.