Of 6 PKC isozymes, PKCβI (Cyto: PC = 0.79, P = .016; Memb: PC = 0.76, P = .015) and PKCβII (Cyto: PC = 0.75, P = .009; Memb: FC = 0.68, P = .015) showed significantly decreased protein expression in cytosol and membrane fraction from PFC of DS subjects (considering PC = 1 for NC). The gene discussed is PRRT2; the disease is Dravet syndrome.