Recurrent mutations were reported in an additional deubiquitinase gene, USP48 (predominantly encoding p.M415I or p.M415V) in 21/91 paediatric subjects with corticotroph adenomas and in the BRAF gene (encoding p.V600E) in 15/91 subjects with wild-type USP8 [26]. This evidence concerns the gene USP8 and ACTH-producing pituitary gland adenoma.