For example, Krabbe disease results from mutations in GALC encoding the enzyme galactosylceramidase, resulting in the accumulation of the cytotoxic lipid psychosine which has been demonstrated to induce to fibrillization of α-synuclein in vitro [113] through direct interactions with its C-terminal region that expose the central amyloidogenic region [1]. This evidence concerns the gene SNCA and Krabbe disease.