Rodent models of Gaucher disease (GBA1) [56], Sandhoff disease (HEXA) [62], Tay–Sachs disease (HEXB) [14], neuronal ceroid lipofuscinosis type 10 (CATD) [21], Krabbe disease (GALC) [113], and Fabry disease (GLA) [83] manifest accumulated insoluble α-synuclein. Here, SNCA is linked to Fabry disease.