SNCA and lysosomal lipid storage disorder: The influence of lipidosis-causing genetic mutations may be two-fold, with both reduced clearance of α-synuclein due to autophagic impairments leading to a state of increased abundance of α-synuclein within cells, combined with the accumulation of lipids known to promote α-synuclein aggregation, as has been demonstrated for GBA1 [119].