The most up-regulated gene RND3/RhoE (+ 235.6-fold) was previously associated with tumor invasion, metastasis and was reported as a potential marker of drug resistance of gastric cancer as well as relapse and prognosis for colorectal cancer cases (Chang et al. 2014; Li et al. 2009; Zhou et al. 2013). This evidence concerns the gene RND3 and neoplasm.