For example, Izumi and Larsen [2] found elevated serum Tg levels in untreated Graves’ disease (GD) patients, 132 ± 124 μg/L (mean ± SD) as opposed to 11 ± 6.4 ug/L in healthy subjects and observed elevations in serum Tg up to 7000 μg/L within 24–48 h after subtotal thyroidectomy or 131I treatment of GD. Here, TG is linked to Graves disease.