In agreement with this study, which was remarkably performed on liver biopsies, but also with another one based on non-invasive FIB-4 score [21], we showed that hypogonadism is frequent among middle-aged HIV-infected patients and it seems to be especially present in patients with high SHBG levels, liver fibrosis and HCV co-infection. This evidence concerns the gene SHBG and Hepatic fibrosis.