The aim of this study was the determination of the prevalence and type of hypogonadism based on cFT, TT, SHBG and LH values in a cohort of middle-aged HIV-infected males with symptomatic hypogonadism and its relationship with liver fibrosis measured by Fibrosis-4 (FIB-4) and aspartate aminotransferase (AST)-to-platelet ratio index (APRI) scores. The gene discussed is PLOD1; the disease is Hepatic fibrosis.