Anti-NEP antibody54,55 screening should be carried out in patients with CNS who have kidney failure at presentation or transient proteinuria at birth that spontaneously resolves within a few weeks; those who have a family history of siblings with congenital membranous nephropathy or transient proteinuria at birth; and those who have membranous nephropathy on kidney biopsy (Box 7). The gene discussed is MME; the disease is kidney failure.