EYS and retinitis pigmentosa: Keeping this in mind, when we specifically looked at retinitis pigmentosa patients who were still genetically unsolved after the NGS panel test11, we found that G843E was highly enriched in patients with a heterozygous deleterious mutation in EYS (allele frequency = 17.0%) compared to those without (allele frequency = 6.9%, odds ratio = 2.46, P = 8.51 × 10−7, Fisher exact test; Table 3) or to the general population using a public database (allele frequency = 1.7%, odds ratio = 10.0, P = 2.21 × 10−32, Fisher exact test; Table 3).