PLXNB2 and glioblastoma: To understand the contribution of Plexin-B2 to GBM invasion, we first examined its expression in GSCs and found that all four GSC lines abundantly expressed Plexin-B2 (Fig. 2a and Supplementary Fig. 3a), in agreement with earlier reports on Plexin-B2 upregulation in gliomas19,22.