PRKAA1 and neoplasm: However, in RasHigh/Lkb1−/− tissue we observed sustained pAmpk levels by Western blot, which was confirmed by immunofluorescence in mosaic imaginal discs (Fig. 5b, c). Recently, the presumed role of Ampk as a tumor suppressor has been challenged by evidence that Ampk can promote metabolic adaptation to effect tumor growth and survival35.