TNFα is a major inflammatory cytokine, having systemic and local activities; IFNγ is having a more local-microenvironment function that was reported specifically to affect cytotoxic T cells via local paracrine and even autocrine fashion53; hypoxia is considered a hallmark of cancer, but levels may range from pO2 of 80 mmHg down to zero, with substantial heterogeneity within tumor microenvironment54. Here, TNF is linked to cancer.