In the present report, dysregulated mRNA-circRNA-miRNAs signature axes were studied using circRNA microarray and miRNA sequencing analysis of nontumorigenic S1 and pretumorigenic Cx43-KO-S1 cells, and microarrays of a validation young patient cohort with early-stage breast cancer47 and large cohort datasets of breast cancer miRnome and transcriptome50,51. Here, GJA1 is linked to neoplasm.