Interestingly, when performed on patients with grade III breast tumors with the exact characteristics, survival analyses revealed poor prognostic association upon the down-regulation of miR-182 in a cohort of 395 patients (Supplementary Fig. 2a) and the up-regulation of Cx43 in a cohort of 903 patients (Supplementary Fig. 2a)50,51. This evidence concerns the gene GJA1 and breast neoplasm.