RUNX2 and breast cancer: miR-3960, which was commonly up-regulated in early breast cancer Lebanese and US patients (matched for stage, histology and metastasis statuses)47, and down-regulated in Cx43-KO-S1 compared to S1 cells was linked to breast cancer-mediated bone metastasis via Runx2/miR-3960/miR-2861 axis67.