This might imply that the down-regulation of hsa_circ_0077755, which is indicative of loss of of Cx43 mRNA expression along breast cancer initiation8, relieves its sponging activity on miR-182 causing an upregulation in its expression, which in turn acts as an oncogene and primers tumor initiation as mentioned earlier68–70. This evidence concerns the gene GJA1 and breast cancer.