To study the role of GOF p53 in tumor formation, these animals were crossbred with mice (TRE CMV.p53 shRNA, CCSP-rtTA) that can express p53 shRNA from a promoter with a tetracycline responsive element (TRE) after Dox-induction specifically in lung Club cells32 due to co-expression of a transactivator (rtTA) from the CCSP promoter33. The gene discussed is TP53; the disease is neoplasm.