GJB6 and Usher syndrome: Recent studies have utilized the trans-vestibular pathway (e.g., canalostomy) for cochleovestibular gene delivery, most of which have investigated GFP expression rather than the expression of therapeutic genes26–29, except for two recent studies in which one used a model of Usher syndrome (Whirlin−/− mice)4 and the other one used Cx30 knockout mice30.