EIF2A and early-onset autosomal dominant Alzheimer disease: For example, p-eIF2α and three stress-responsive kinases (PKR, PERK, GCN2) are activated in Alzheimer’s disease, owing to the unfolded protein response triggered by Aβ aggregates, and tau oligomers.4 The increased p-eIF2α could further exacerbate memory loss, forming a vicious cycle.