Mitophagy inhibition by cyclosporine A partially eliminated the protective effects of melatonin.162 In vitro cell culture and in vivo rat model study showed that melatonin delayed the progression of IL-1β-induced IVDD and related LBP via inhibiting the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop, and downregulating mitochondrial reactive oxygen species (mtROS) production, suggesting melatonin might be a considerable potential clinical agent for IVDD.163. Here, IL1B is linked to Low back pain.