In striking contrast, TLS analyses with a variety of DNA lesions present on the template for leading or lagging strand replication of a duplex plasmid carried in normal human cells (not derived from cancers) have shown that Rev1 functions together with Y-family Pols η, ι, or κ and not with ζ (Yoon et al, 2019a, 2018, 2017, 2015). Here, REV1 is linked to cancer.