However and strikingly, c-jun deletion in the c-junf/f;Mx-cre mice led to a consistent decrease in fibrosis (% Sirius red staining of CCl4-treated livers: without or with Mx-cre – 4.698 ± 0.709 versus 4.018 ± 0.476; P = 0.033) (Fig 1D, right), indicating that c-jun deletion in hepatocytes alone or in combination with KCs result in differential outcomes. This evidence concerns the gene JUN and dry eye syndrome.