BRCA1 and breast carcinoma: High-penetrance genetic variants have been include in the Tyrer-Cuzick, BOADICEA and BRCAPRO models for breast cancer risk prediction, which use BRCA1/2 mutation carrier status as a risk factor.106 In recent years, research has demonstrated the efficacy of employing a polygenic risk score (PRS) of low-penetrance SNPs in disease risk prediction.