A notable exception is the rare cancer predisposition syndrome, Li Fraumeni syndrome, arising from germline TP53 pathogenic variants.75 While typically associated with sarcoma, breast and brain tumours, leukaemia, lymphoma and adrenocortical carcinoma, instances of lung cancer in Li Fraumeni syndrome have also been described.76 77. This evidence concerns the gene TP53 and Li-Fraumeni syndrome.