(-)-Epigallocatechin gallate (EGCG) is active catechin isolated from green tea, which suppresses tumor growth and enhances drug sensitivity in various cancers, available data show that EGCG serves as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU [83]. The gene discussed is HSPA5; the disease is neoplasm.