2-(3,4-dihydroxy phenyl) ethanol (DPE), a phenol antioxidant derived from olive oil, triggers growth arrest and apoptosis in human colon carcinoma HT-29 cells through the activation of the IRE1-JNK pathway and PERK-eIF2α-CHOP pathway [121]. Here, EIF2AK3 is linked to colon carcinoma.