As also observed in cells from DC patients, DKC1 interference with iDKC1- and iDKC4-LVs induced markers of DNA damage, cell senescence, and apoptosis, such as the generation of nuclear γH2AX foci and upregulation of caspase 3, p21, and phosphorylated p53. This evidence concerns the gene CDKN1A and dyskeratosis congenita.