The results might be analyzed in the following three aspects: Firstly, with the accumulation of visceral fat, some pro-inflammatory cytokines, such as IL-6, IL-8, monocyte chemoattractant protein 1 (MPC-1), and tumor necrosis factor α (TNF-α), secreted or induced by adipose tissue can lead to low-grade inflammation and oxidative stress, and further cause insulin resistance. The gene discussed is TNF; the disease is Insulin resistance.