Although the commonly shared variant of HLA-DRB1 Val11 also increased the risk of ACPA-positive RA among the Indian patients, this association did not reach the genome-wide significant threshold (OR = 1.99, 95% CI = 1.52–2.61, PGWAS = 6.60 × 10−07) (supplementary Table 5). This evidence concerns the gene PRTN3 and rheumatoid arthritis.