Our findings in the Chinese ethnic group showed that HLA-DRB1*04:05 allele was the top association signal for risk of ACPA-positive RA (OR = 5.22, 95% CI = 2.95–9.25, PGWAS = 1.52 × 10−08) (Table 2), in agreement with the previously published data using the experimental classical HLA genotype dataset [9]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.