Conditioning by the most associated risk variant, i.e., HLA-DRB1 Val11, with ACPA-positive RA in the Malay ethnic group revealed an inverse association of HLA-DQB1*03:02 allele with risk of developing ACPA-positive RA (OR = 0.17, 95% CI = 0.09–0.30, PGWAS = 1.60 × 10−09) (Fig. 1). The gene discussed is PRTN3; the disease is rheumatoid arthritis.