Meanwhile, we observed the Val11-Phe13-Arg71-Ala74 haplotype was associated with increased risk of ACPA-positive RA in the Malays (OR = 4.35, 95% CI = 2.27–8.32, p = 9.78 × 10−06) and Indians (OR = 2.00, 95% CI = 1.10–3.68, p = 0.03), but not in the Chinese. Here, PRTN3 is linked to rheumatoid arthritis.