Interestingly, while Ser11-Ser13-Glx71-Ala74 conferred significant risk for ACPA-positive RA among the Chinese (OR = 12.91, 95% CI = 2.55–65.34, p = 6.98 × 10−04), it demonstrated an inverse association to ACPA-positive RA in the Indian population (OR = 0.40, 95% CI = 0.18–0.86, p = 0.03). The gene discussed is PRTN3; the disease is rheumatoid arthritis.