Our observations implied that we have convincingly replicated the previous published data showing the association of the HLA-DRB1*04:05 allele (i.e., corresponding to HLA-DRB1 Val11 and HLA-DRB1 Asn120) with increased risk of ACPA-positive RA in the Malay ethnic group [9]. Here, PRTN3 is linked to rheumatoid arthritis.