In this setting, ACE2 polymorphism and its association with hypertension were reported in different populations including the Chinese population with three major ACE2 variants (rs4830542, rs4240157, and rs4646155) [59], the Canadian population with another three different variants (rs233575, rs2074192, and rs2158083) [60], the Brazilian population with ACE2 G8790A mutation in combination with ACE I/D [61], and the Indian population with the ACE2 rs2106809 mutant [62]. The gene discussed is ACE2; the disease is hypertensive disorder.