After 24-h co-incubation of tumor cells and effector T cells at an E:T ratio of 10:1, B7-H3 CAR-T cells produced significantly higher amounts of IFN-γ, TNF-α, IL-2, IL-6, IL-4 and IL-10 in the culture supernatants compared with vehicle T cells (Fig. 4a). This evidence concerns the gene IL6 and neoplasm.