Dynamics of tumor cell death induced by NK cells was observed using FRET-based quantitative live cell imaging system in which activation of caspase-3 was used as indication of apoptosis. As NK stimulation by BiKE leads to significant increases in apoptotic target cell death, this further confirmed ﻿the ability of BiKE to actively propagate signals for NK cell activation. The gene discussed is CASP3; the disease is neoplasm.