A ViSEN analysis and plot for the Alzheimer’s dataset (Fig. 3a) revealed one SNP with large independent effect affiliated with ApoE gene (rs429358, MI 0.08) – a known risk factor for Alzheimer disease, and three strong two-way gene-gene interactions (rs4955208 - rs7782571, IG 0.05; rs12785149 - rs12209418, IG 0.05; rs2414325 - rs1931073, IG 0.05). The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.