G6PD and cancer: In cell lines, G6PD expression mRNA and protein levels were dramatically high-expressed in different gastric cancer cell line (AGS, MGC-803, SGC-7901 and MKN-45 cells) compared with human gastric epithelial cell line (GES-1) and found that G6PD expression was higher in MGC-803 and AGS cells in four cancer cells (P < 0.01, Fig. 1f, g).