Although the efficacy of disopyramide, quinidine, and propafenone on human atrial patho-electrophysiology associated with human Ether-à-go-go-Related Gene(hERG) -linked short QT syndrome has been investigated using a multi-scale computational model [37], mechanisms by which short QT mutations promote AF may be different from that underlying Pitx2-induced AF [27,28,29,30,31,32,36]. The gene discussed is KCNH2; the disease is atrial fibrillation.