Here, NFAT members bind to DNA and induce the expression of different proinflammatory cytokines and proteins, mainly TNF, IL-2, CD40 ligand (CD40-L), IL17 and IFNγ, highly implicated in the pathogenesis of SLE [2,55,69,70,71,72]. This evidence concerns the gene IFNG and systemic lupus erythematosus.