FBN2 and Vascular dilatation: Loss-of-function mutations in FBN2, the gene coding for fibrillin-2, cause congenital contractural arachnodactyly; although these mutations are associated with aortic dilatation and dissection in some patients, TAA is not a common phenotype, which is likely a consequence of the compensatory effect of fibrillin-1 [200,201]