Similarly, DFS was significantly affected by larger tumor size (HR: 1.8; 95% CI = 1.0, 3.2; p = 0.034), presence of necrosis (HR: 1.8; 95% CI = 1.0, 3.1; p = 0.004), vascular invasion (HR: 2.5; 95% CI = 1.4, 4.2; p = 0.001), ID1 (HR: 2.0; 95% CI = 1.1, 3.6; p = 0.016), and ID4 overexpression (HR: 3.4; 95% CI = 1.9, 6.0; p <0.001). This evidence concerns the gene ID4 and neoplasm.