HOXA11 and cancer: Homeobox A11 antisense RNA (HOXA11-AS) is a highly conserved lncRNA located in the HOXA gene cluster on chromosome 7p15.2, at the opposite strand of the protein-coding gene, HOXA11. HOXA11-AS initiates tumor formation and metastasis [8]; it functions as an oncogene in many types of cancers by regulating polycomb repressive complex 2 (PRC2) [9] and acting as a sponge for microRNAs [10,11].