ITGA2 and Familial prostate cancer: Sottnik et al. [50] showed that ITGA2:ITGB1 (α2β1) integrin was elevated in prostate cancer skeletal metastases, compared with either prostate cancer primary lesions or soft tissue metastases; this finding suggests that ITGA2:ITGB1 integrin contributes to selective metastasis to the bone.