ITGB4 and metastatic prostate carcinoma: Among the eight integrin subunits analyzed, ITGA5, ITGAV, ITGB1, ITGB3, ITGB4, and ITGB5 were upregulated in the bone compared with the other organs, suggesting that some integrins may confer osteotropic properties on metastatic prostate cancer (Figure 3D).