Furthermore, integrin β1 or β3 mediated mechanotransduction is correlated with LOX expression in clear cell renal cell carcinoma [90] and LOXL2 expression in fibroblasts [91], respectively, and is known to activate the FAK/Src or PI3K/Akt signaling pathways (Figure 3). The gene discussed is LOX; the disease is clear cell renal carcinoma.