Increases in LOX, LOXL2 and LOXL4 expression in the ECM of cancer is linked to an increase in focal adhesion kinase (FAK) and Src phosphorylation in colorectal adenocarcinoma [88,89], gastric cancer [53,56], clear cell renal cell carcinoma [90] and fibroblasts [91]. The gene discussed is LOX; the disease is colorectal adenocarcinoma.