These tumors have large numbers of subclonal mutations related to late events and exhibit frequent chromosomal instability associated with the CIN subtype, TP53 mutations, and APOBEC-related mutational signatures (previously related to the Epstein–Barr virus (EBV) gastric cancer subtype) [6,46]. This evidence concerns the gene TP53 and cervical squamous intraepithelial neoplasia.