Of the 24 significantly mutated genes identified in the S4low group, 12 were oncogenes associated with tumor progression or tumor suppressor genes (PIK3CA, KRAS, RHOA, CDH1, CTNNB1, ITGAV, SMAD4, TP53, CDKN2A, APC, PTEN, and PIK3R1; Table S1c). The gene discussed is CDH1; the disease is neoplasm.