FAF imaging highlights further the greater regional disease severity of PT3, revealing large confluent nummular patches of dense hypo-AF at the temporal arcades due to a combination of atrophic RPE and blockage from the nummular pigment deposits, and faint hyper-AF at and inside the arcades with both a diffuse and a speckled pattern (Figure 2D). The gene discussed is ZNF135; the disease is atrial fibrillation.