IL10 and Parkinson disease: Conversely, in agreement with Zhao and colleagues [62], in case of stress, PD activates the antioxidant pathway and blocks the ROS-driven inflammasome activation, and as herein observed, induced a lower activation of the immune system by modulating the expression of the pro-inflammatory cytokines il1 and cxcl8b.1 and regulating the anti-inflammatory cytokine il10 mRNA levels.