On the other hand, the physicochemical properties of the cation make essential the activity of Mg2+ transporters that allow its flux across cell membranes participating in the processes of intake, excretion and reabsorption [83] In this aspect, although several transporters such as the cyclin M family (CNNM), magnesium transporter 1 (MagT1), MRS2 or the solute carrier family 41 (SLC41) have been characterized [84,85,86], their potential role in the development of NASH and related comorbidities remains largely unknown. This evidence concerns the gene MRS2 and metabolic dysfunction-associated steatohepatitis.