Gene set enrichment analysis (GSEA) of HPV-positive and negative head and neck cancer (HNC) TCGA samples revealed significant enrichment of the DREAM target genes in the differentially expressed gene sets (Figure 1D, GSEA p-value = 1.00 × 10−10), as well as their upregulation in HPV+ tumors (Figure 1E). This evidence concerns the gene KCNIP3 and head and neck cancer.