TCGA-ACC dataset registered the most mutated genes in ACC, including TP53 (21%), ZNRF3 (19%), CDKN2A (15%), CTNNB1 (16%), TERT (14%), and PPKAR1A (11%), while the ATRX gene had a frequency of 4.3% of cohort [31]. The gene discussed is ZNRF3; the disease is adrenal cortex carcinoma.