IL6 and Cowden syndrome 1: A recent study showed that the levels of IL-6, IL-10 and MCP-1, but not IL-1b, were associated with shock severity in a heterogenous cohort of CS patients [26], and previous studies reported that inflammation-associated cytokines as TNF-α, IL-6 and IL-1Ra are significantly elevated in patients with CS-AMI compared to patients with uncomplicated MI [27].