IL-1α and IL-1β are both agonists of the IL1R; IL-1α is released by necrotic cardiomyocytes and functions as an alarm signal, triggering a postinfarction inflammatory reaction, while IL-1β is produced by the leukocytes invading the infarct area after myocardial infarction [28]. Here, IL1B is linked to myocardial infarction.