Among these overrepresented genes, we focused on 12 genes previously reported to be tumor/invasion suppressor genes (i.e., BHLHE41 (also known as SHARP1), CDKN2A, CHMP1A, DDB2, DRD2, EMILIN1, GATA2, ING5, LCN2, NOG, RUNX1, and SMAD5) [19,29,30,31,32,33,34,35,36,37,38,39] (Table S4) and performed quantitative polymerase chain reaction (qPCR) to investigate whether these suppressor genes are downregulated by the overexpression of miR-675-5p in HTR-8/SVneo cells. This evidence concerns the gene SMAD5 and neoplasm.